Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 180
interventional 115
Observational 52
Registry 13

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Device 76
Procedure 14
Drug 6
Device|Other 4
Device|Procedure 4
Diagnostic Test 2
Drug|placebo 2
Drug|Procedure 2
Behavioral 1
Device|Drug 1
Drug|Other 1
Other|placebo 1
Other|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 27
Germany 7
Canada 5
United States|Canada 5
Korea, Republic of 4
Australia 3
China 3
Poland 3
Russian Federation 3
Austria 2
France 2
Lithuania 2
NA 2
Switzerland 2
Australia|France|Latvia|United Kingdom 1
Australia|Poland 1
Austria|Germany|Italy|Switzerland 1
Austria|Germany|Lithuania 1
Belgium 1
Belgium|Czechia|Israel|Italy 1
Belgium|Germany|Greece|Norway|Poland 1
Belgium|Germany|Netherlands 1
Belgium|Italy 1
Brazil 1
Brazil|Germany|Switzerland 1
Brazil|Paraguay 1
Canada|France|Germany|Hungary|Netherlands|Panama|Poland 1
Colombia 1
Czechia|Denmark|Germany|Greece|Italy|Poland|Portugal|Spain|United Kingdom 1
Czechia|France 1
Denmark|Germany|Italy|Lithuania 1
Finland 1
France|Australia|Czechia|Germany|Netherlands|New Zealand|Poland|United Kingdom 1
France|Germany 1
France|Germany|Italy 1
France|Germany|Netherlands|Switzerland 1
France|Monaco 1
Germany|Israel|Italy|Netherlands|Spain|United Kingdom 1
Germany|Italy|Netherlands 1
Germany|Italy|Switzerland 1
Italy|Poland 1
Italy|United Kingdom 1
Japan 1
Poland|United Kingdom 1
Taiwan 1
United Kingdom 1
United States|Australia|Canada 1
United States|Australia|Canada|Germany|Greece|Italy|Switzerland 1
United States|Australia|France|Germany|Italy|Netherlands|Norway|Sweden|Switzerland|United Kingdom 1
United States|Austria|Belgium|Canada|Germany|Switzerland 1
United States|Belgium|Canada 1
United States|Canada|Denmark 1
United States|Canada|Germany 1
United States|Canada|Japan 1
United States|Canada|Poland 1
United States|Denmark 1
United States|France|Greece|Poland|United Kingdom 1
United States|Korea, Republic of 1
United States|Paraguay 1

Sites per Study

Site_count Study_Count
1 48
2 11
3 4
4 4
5 4
6 3
7 1
8 3
9 2
10 6
11 1
12 1
13 1
16 1
17 4
18 3
19 1
20 1
21 2
24 1
25 1
27 1
31 2
32 1
34 1
38 2
40 1
45 1
56 1
61 1
86 1

Phase

Phase Study_Count
N/A 91
Phase 4 8
Phase 3 6
Phase 2 5
Phase 1 2
Phase 1/Phase 2 2
Phase 2/Phase 3 1

Number of Arms

Number_of_Arms Count_of_Studies
1 62
2 36
3 3
4 4
6 2
NA 8

Enrollment Metrics by Phase

Measure N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 1.0000 5.00 4.00 30.0 38 20.0000 34.000
1st Qu. 15.5000 6.75 16.75 250.0 38 65.5000 60.000
Median 60.0000 8.50 29.50 251.0 38 175.5000 68.500
Mean 174.8571 8.50 29.50 218.2 38 332.8333 117.375
3rd Qu. 220.0000 10.25 42.25 260.0 38 285.5000 121.000
Max. 1600.0000 12.00 55.00 300.0 38 1275.0000 400.000

Trial Group Type

group_type Group_Count
Experimental 102
Active Comparator 31
Other 21
No Intervention 13
NA 8
Placebo Comparator 4

Intervention Model

intervention_model Study_Count
Single Group Assignment 69
Parallel Assignment 43
Crossover Assignment 2
Factorial Assignment 1

Primary Purpose

primary_purpose Study_Count
Treatment 102
Diagnostic 4
Device Feasibility 3
Supportive Care 3
Other 1
Prevention 1
NA 1

Observational Studies

Studies by Country

Country Study_Count
United States 16
NA 4
United Kingdom 4
Israel 3
France 2
Italy 2
Korea, Republic of 2
Norway 2
Austria 1
Austria|Germany|Italy 1
Belgium|Canada|France 1
Canada 1
Canada|Czechia|France|Germany|Italy 1
Czechia 1
Finland 1
Germany|Italy 1
Germany|Italy|Switzerland 1
Germany|Switzerland 1
Greece 1
Japan 1
Netherlands 1
Switzerland 1
Taiwan 1
United States|Canada 1
United States|Germany|Israel|Italy|Netherlands|Spain|Switzerland|United Kingdom 1

Sites per Study

Site_count Study_Count
1 38
2 4
3 1
4 1
6 1
7 1
15 2
17 1
24 1
40 1
57 1

Enrollment Metrics

Measure Observational
Min 3
1st Qu 50
Median 100
Mean 769
3rd Qu 277
Max 15000

Observation Model

observational_model Study_Count
Cohort 37
Case-Only 5
Case-Control 4
NA 3
Other 2
Case Control 1

Time Perspective

time_perspective Study_Count
Prospective 36
Retrospective 9
Cross-Sectional 5
Other 1
NA 1

Registries

Studies by Country

Country Study_Count
Germany 3
Italy 3
Belgium 1
France 1
France|Germany|Italy|Lithuania|Switzerland 1
Germany|Switzerland 1
Netherlands 1
Switzerland 1
United States 1

Sites per Study

Site_count Study_Count
1 6
2 1
3 1
4 1
6 1
7 1
14 1
20 1

Enrollment Metrics

Measure Registries
Min 12.0000
1st Qu 200.0000
Median 220.0000
Mean 358.3077
3rd Qu 400.0000
Max 1500.0000

Registry Model

observational_model Study_Count
Cohort 10
Case-Only 2
Case-Control 1

Time Perspective

time_perspective Study_Count
Prospective 11
Other 2

Follow-up

target_duration Study_Count
2 Years 4
5 Years 4
1 Year 2
12 Months 2
10 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT03366649 Improving Mitral Repair for Functional Mitral Regurgitation https://ClinicalTrials.gov/show/NCT03366649 Recruiting Emory University 2023-12-31
NCT03339115 AHEAD: European Feasibility Study of the Cardiovalve Transfemoral Mitral Valve System https://ClinicalTrials.gov/show/NCT03339115 Recruiting Cardiovalve Ltd. 2020-12-15
NCT03315429 Unmasking the dynAmic Component in functionaL mitraL rEGuRgitatiOn in Chronic Heart Failure https://ClinicalTrials.gov/show/NCT03315429 Recruiting Medical University of Vienna 2018-10-31
NCT03311295 MitrAl ValvE RepaIr Clinical Trial (MAVERIC Trial) - United States https://ClinicalTrials.gov/show/NCT03311295 Recruiting Mvrx, Inc. 2019-02-03
NCT03292497 Prospective Treatment Algorithm Guiding Repair of Severe Ischemic Mitral Regurgitation https://ClinicalTrials.gov/show/NCT03292497 Active, not recruiting Ottawa Heart Institute Research Corporation 2020-11-30
NCT03286088 Mitral Valve Regurgitation Quantification From 3D Color Doppler Ultrasound - Standard of Care Data Collection https://ClinicalTrials.gov/show/NCT03286088 Recruiting Philips Electronics Nederland B.V. acting through Philips CTO organization 2019-06-30
NCT03278574 Flexible Band vs Rigid Ring for Degenerative Mitral Valve Disease https://ClinicalTrials.gov/show/NCT03278574 Completed Meshalkin Research Institute of Pathology of Circulation 2014-09-29
NCT03271762 Multicentre Study of MITRACLIP® Transcatheter Mitral Valve Repair in Patients With Severe Primary Mitral Regurgitation Eligible for High-risk Surgery https://ClinicalTrials.gov/show/NCT03271762 Recruiting Nantes University Hospital 2022-03-31
NCT03270514 Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride https://ClinicalTrials.gov/show/NCT03270514 Completed University of Pittsburgh 2019-12-13
NCT03242642 Transcatheter Mitral Valve Replacement With the Medtronic Intrepidâ„¢ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation https://ClinicalTrials.gov/show/NCT03242642 Recruiting Medtronic Cardiovascular 2021-10-31
NCT03228381 The BOSS Study: An Acute Evaluation of Anatomical and Geometric Changes Using the Bladder on a Stick System (BOSS) https://ClinicalTrials.gov/show/NCT03228381 Completed Mardil Medical 2017-10-16
NCT03193801 PARTNER 3 Trial - Mitral Valve in Valve https://ClinicalTrials.gov/show/NCT03193801 Recruiting Edwards Lifesciences 2020-08-01
NCT03142152 The CARILLON Trial - Assessment of the Carillon® Mitral Contour System® in Treating Functional Mitral Regurgitation Associated With Heart Failure https://ClinicalTrials.gov/show/NCT03142152 Active, not recruiting Cardiac Dimensions Pty Ltd 2022-10-01
NCT03104660 Coronary and Structural Interventions Ulm - Transcatheter Mitral Valve Repair (CSI-Ulm-TMVR) https://ClinicalTrials.gov/show/NCT03104660 Completed University of Ulm 2018-12-31
NCT03039855 Tiaraâ„¢ Transcatheter Mitral Valve Replacement Study https://ClinicalTrials.gov/show/NCT03039855 Recruiting Neovasc Inc. 2020-01-31
NCT03016975 Edwards Cardioband System ACTIVE Pivotal Clinical Trial (ACTIVE) https://ClinicalTrials.gov/show/NCT03016975 Active, not recruiting Edwards Lifesciences 2020-09-30
NCT02996552 Annuloplasty for Not-Severe TR in Patients Undergoing MV Repair Versus Mitral Repair Only (NOSTRUM) https://ClinicalTrials.gov/show/NCT02996552 Recruiting Ospedale San Raffaele 2019-06-30
NCT02974881 HighLifeâ„¢ Transcatheter Mitral Valve Replacement System Study https://ClinicalTrials.gov/show/NCT02974881 Active, not recruiting HighLife SAS 2018-11-18
NCT02948231 MERIT Study - Mistral Percutaneous Mitral Valve Repair FIM Study https://ClinicalTrials.gov/show/NCT02948231 Recruiting Mitralix 2020-01-31
NCT02806570 Early Feasibility Study of the AccuCinch® Ventricular Repair System - The CorCinch-FMR Study https://ClinicalTrials.gov/show/NCT02806570 Active, not recruiting Ancora Heart, Inc. 2020-01-31
NCT02803957 Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair https://ClinicalTrials.gov/show/NCT02803957 Recruiting NeoChord 2022-07-31
NCT02768870 CE Mark Study for the Harpoon Medical Device https://ClinicalTrials.gov/show/NCT02768870 Active, not recruiting Edwards Lifesciences 2017-11-30
NCT02768402 Caisson Transcatheter Mitral Valve Replacement (TMVR) System Early Feasibility Study https://ClinicalTrials.gov/show/NCT02768402 Active, not recruiting Caisson Interventional LLC 2023-09-30
NCT02728739 Incidence of Significant Mitral Regurgitation in Acute Heart Failure Patients https://ClinicalTrials.gov/show/NCT02728739 Completed Metanoic Health Ltd. 2017-12-29
NCT02718001 Edwards EVOQUE TMVR Early Feasibility Study https://ClinicalTrials.gov/show/NCT02718001 Recruiting Edwards Lifesciences 2024-12-31
NCT02703311 REPAIR - transcatheteR rEPair of mitrAl Insufficiency With caRdioband System https://ClinicalTrials.gov/show/NCT02703311 Completed Edwards Lifesciences 2017-11-30
NCT02701972 Evaluation of Safety and Efficacy of the BACEâ„¢ Device in the Treatment of Functional Mitral Valve Regurgitation [FMR https://ClinicalTrials.gov/show/NCT02701972 Enrolling by invitation Phoenix Cardiac Devices, Inc. 2020-06-30
NCT02687932 Pharmacological Reduction of Functional, Ischemic Mitral REgurgitation https://ClinicalTrials.gov/show/NCT02687932 Completed Asan Medical Center 2018-01-02
NCT02671799 Evaluation of the Minimally Invasive VenTouchâ„¢ System in the Treatment of Functional Mitral Valve Regurgitation (FMR) https://ClinicalTrials.gov/show/NCT02671799 Active, not recruiting Mardil Medical 2017-07-04
NCT02607527 Annular Reshaping of the Mitral Valve for Patients With Mitral Regurgitation Using the Millipede IRIS System https://ClinicalTrials.gov/show/NCT02607527 Completed Millipede Inc. 2019-01-17
NCT02602613 AMENDTM Mitral Valve Repair System, Annuloplasty Ring Applied in a Transcatheter Method https://ClinicalTrials.gov/show/NCT02602613 Completed Valcare Medical Ltd. 2018-12-31
NCT02321514 Expanded Clinical Study of the Tendyne Mitral Valve System https://ClinicalTrials.gov/show/NCT02321514 Active, not recruiting Abbott Medical Devices 2020-07-31
NCT03389542 Early Mitral ValvE Repair Versus Watchful Waiting for Asymptomatic SEvere Degenerative Mitral Regurgitation https://ClinicalTrials.gov/show/NCT03389542 Recruiting Centre Hospitalier Universitaire, Amiens 2025-01-01
NCT02502448 Acute Normovolemic Hemodilution on ROTEM in Cardiac Surgery https://ClinicalTrials.gov/show/NCT02502448 Completed Konkuk University Medical Center 2016-06-30
NCT02471664 Mitral Loop Cerclage(MLC) for Reducing Functional Mitral Regurgitation https://ClinicalTrials.gov/show/NCT02471664 Completed Tau Pnu Medical Co., Ltd. 2016-03-31
NCT02444338 A Clinical Evaluation of the Safety and Effectiveness of the MitraClip System in the Treatment of Clinically Significant Functional Mitral Regurgitation https://ClinicalTrials.gov/show/NCT02444338 Recruiting Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH 2021-03-31
NCT02432196 CE Mark Study for the Harpoon Medical Device in Poland https://ClinicalTrials.gov/show/NCT02432196 Active, not recruiting Edwards Lifesciences 2017-12-31
NCT02428010 Twelve Transcatheter Mitral Valve Replacement (TMVR) Pilot Study https://ClinicalTrials.gov/show/NCT02428010 Active, not recruiting Medtronic Cardiovascular 2020-07-31
NCT02375282 Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study https://ClinicalTrials.gov/show/NCT02375282 Completed Baystate Medical Center 2015-07-31
NCT02325830 CARILLON Mitral Contour System® for Reducing Functional Mitral Regurgitation https://ClinicalTrials.gov/show/NCT02325830 Completed Cardiac Dimensions Pty Ltd 2018-07-31
NCT02302872 Treatment of Heart Failure and Associated Functional Mitral Valve Regurgitation https://ClinicalTrials.gov/show/NCT02302872 Recruiting Mvrx, Inc. 2019-10-31
NCT02276547 Early Feasibility Study of the Neovasc Tiaraâ„¢ Mitral Valve System https://ClinicalTrials.gov/show/NCT02276547 Active, not recruiting Neovasc Inc. 2019-12-06
NCT02180893 The Use of Paravertebral Block for Cardiac Surgery https://ClinicalTrials.gov/show/NCT02180893 Completed NYU Langone Health 2014-04-30
NCT02153892 Feasibility of the AccuCinch® System for Left Ventricular Reshaping of the Mitral Apparatus to Reduce Functional Mitral Regurgitation and Improve Left Ventricular Function https://ClinicalTrials.gov/show/NCT02153892 Completed Ancora Heart, Inc. 2015-10-31
NCT02054221 Surgical Treatment of Hypertrophic Obstructive Cardiomyopathy With Severe Mitral Insufficiency. https://ClinicalTrials.gov/show/NCT02054221 Completed Meshalkin Research Institute of Pathology of Circulation 2015-05-31
NCT01940120 EVEREST II Pivotal Study High Risk Registry (HRR) https://ClinicalTrials.gov/show/NCT01940120 Completed Abbott Medical Devices 2008-03-31
NCT01920698 Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation https://ClinicalTrials.gov/show/NCT01920698 Active, not recruiting Hospices Civils de Lyon 2018-04-30
NCT01899573 Percutaneous Left Ventricular Reshaping to Reduce Functional Mitral Regurgitation and Improve LV Function https://ClinicalTrials.gov/show/NCT01899573 Completed Ancora Heart, Inc. 2016-01-31
NCT01852149 Mitralign Percutaneous Annuloplasty First in Man Study https://ClinicalTrials.gov/show/NCT01852149 Completed Mitralign, Inc. 2014-03-31
NCT01841554 Cardioband With Transfemoral Delivery System https://ClinicalTrials.gov/show/NCT01841554 Completed Edwards Lifesciences 2016-08-31
NCT01777815 Safety and Performance Study of the NeoChord Device https://ClinicalTrials.gov/show/NCT01777815 Completed NeoChord 2012-10-31
NCT01757665 ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE) https://ClinicalTrials.gov/show/NCT01757665 Active, not recruiting Edwards Lifesciences 2017-08-31
NCT01641614 Beating Versus Arrested Heart for Mitral Valve Replacement https://ClinicalTrials.gov/show/NCT01641614 Completed Federal University of Bahia 2011-03-31
NCT01626079 Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) https://ClinicalTrials.gov/show/NCT01626079 Active, not recruiting Abbott Medical Devices 2019-03-31
NCT01621971 Effect of Brief Nebulization of Milrinone on Pulmonary Arterial Pressure Before Cardiopulmonary Bypass on Mitral Valve Surgery Patients https://ClinicalTrials.gov/show/NCT01621971 Completed Konkuk University Medical Center 2004-01-31
NCT04350372 MitraClip Russia Trial https://ClinicalTrials.gov/show/NCT04350372 Recruiting Abbott Medical Devices 2020-05-30
NCT04245956 Impact of Mitral Regurgitation on Coronary Haemodynamics and Instantaneous Effect of Transcatheter Mitral Valve Repair https://ClinicalTrials.gov/show/NCT04245956 Recruiting University Hospital, Geneva 2021-08-15
NCT04217135 The Prognostic Impact of Using High-dose Hydralazine in Severe Systolic Heart Failure With Hemodynamically Significant Mitral Regurgitation https://ClinicalTrials.gov/show/NCT04217135 Recruiting Kaohsiung Veterans General Hospital. 2021-07-31
NCT04147884 A Feasibility Study of the Millipede Transcatheter Annuloplasty Ring System in Patients With Functional Mitral Regurgitation https://ClinicalTrials.gov/show/NCT04147884 Recruiting Boston Scientific Corporation 2020-12-31
NCT04080362 Safety and Performance Study of the MitralStitch Repair System. https://ClinicalTrials.gov/show/NCT04080362 Enrolling by invitation Hangzhou Valgen Medtech Co., Ltd 2021-06-01
NCT04061837 MitralStitch Mitral Valve Repair System for Mitral Regurgitation https://ClinicalTrials.gov/show/NCT04061837 Enrolling by invitation Xijing Hospital 2020-10-31
NCT04029363 Feasibility Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk https://ClinicalTrials.gov/show/NCT04029363 Recruiting HighLife SAS 2020-07-31
NCT04023058 Stress Echo for Ischemic Mitral Valve Surgery https://ClinicalTrials.gov/show/NCT04023058 Recruiting Saint Petersburg State University, Russia 2024-12-31
NCT04009434 Treatment of Concomitant Mitral Regurgitation by Mitral Valve Clipping in Patients With Successful Transcatheter Aortic Valve Implantation. https://ClinicalTrials.gov/show/NCT04009434 Recruiting Technische Universität Dresden 2023-08-01
NCT03997305 AltaValve Early Feasibility Study Protocol https://ClinicalTrials.gov/show/NCT03997305 Recruiting 4C Medical Technologies, Inc. 2020-10-31
NCT03993938 Pleth Variability Index (PVI) as a Measure of Volume Status During Transcatheter Mitral Valve Repair https://ClinicalTrials.gov/show/NCT03993938 Recruiting Henry Ford Health System 2020-04-01
NCT03988946 Cephea Transseptal Mitral Valve System FIH https://ClinicalTrials.gov/show/NCT03988946 Completed Cephea Valve Technologies 2019-12-31
NCT03958773 Cardiovalve Transfemoral System - FIM Study https://ClinicalTrials.gov/show/NCT03958773 Recruiting Cardiovalve Ltd. 2020-09-12
NCT03908983 OPtimisation of Surgical Repair for Treating Insufficiency of the MItral Valve - Safety and Effectiveness Evaluation https://ClinicalTrials.gov/show/NCT03908983 Recruiting Kephalios 2021-05-31
NCT03842397 OPtimisation of Surgical Repair for Treating Insufficiency of the MItral Valve - Safety Evaluation https://ClinicalTrials.gov/show/NCT03842397 Completed Kephalios 2018-07-02
NCT03813524 Cardiovalve Transfemoral Mitral Valve System https://ClinicalTrials.gov/show/NCT03813524 Recruiting Boston Biomedical Associates 2020-04-30
NCT03706833 Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial https://ClinicalTrials.gov/show/NCT03706833 Recruiting Edwards Lifesciences 2023-12-31
NCT03705312 MitraClip for the Treatment of Moderate Functional Mitral Regurgitation: EVOLVE-MR https://ClinicalTrials.gov/show/NCT03705312 Recruiting Montreal Heart Institute 2021-12-31
NCT03661398 Caisson Transcatheter Mitral Valve Replacement (TMVR) https://ClinicalTrials.gov/show/NCT03661398 Active, not recruiting Caisson Interventional LLC 2020-08-31
NCT03616678 VenTouch OUS Feasibility Study https://ClinicalTrials.gov/show/NCT03616678 Recruiting Mardil Medical 2020-05-31
NCT03581656 ChordArt System for Mitral Regurgitation https://ClinicalTrials.gov/show/NCT03581656 Recruiting CoreMedic GmbH 2018-09-30
NCT03560167 Early Feasibility Study of the AccuCinch® Ventricular Repair System in Patients With Prior Mitral Valve Intervention (PMVI) and Recurrent Mitral Regurgitation - The CorCinch-PMVI Study https://ClinicalTrials.gov/show/NCT03560167 Recruiting Ancora Heart, Inc. 2020-08-30
NCT03539458 Feasibility Study of the Tendyne Mitral Valve System for Use in Subjects With Mitral Annular Calcification https://ClinicalTrials.gov/show/NCT03539458 Active, not recruiting Abbott Medical Devices 2019-10-28
NCT03525041 Mitral Valve Repair Combined Coronary Artery Bypass Grafting(CABG) Verus CABG Alone on Functional Ischemic Mitral Regurgitation https://ClinicalTrials.gov/show/NCT03525041 Recruiting Beijing Anzhen Hospital 2019-12-31
NCT03470246 Personalized Activity Intervention in Rehabilitation After Cardiac Operations (the PACO Trial) https://ClinicalTrials.gov/show/NCT03470246 Recruiting Kuopio University Hospital 2022-01-31
NCT03453853 Atrial Functional Mitral Regurgitation Response In Mitral Loop Cerclage Annuloplasty (AFRICA Study) https://ClinicalTrials.gov/show/NCT03453853 Recruiting Tau Pnu Medical Co., Ltd. 2020-03-31
NCT03433274 Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation https://ClinicalTrials.gov/show/NCT03433274 Recruiting Abbott Medical Devices 2022-06-30
NCT01166841 The Effect of Percutaneous Superior Venae Cava Cannulation Clamping on Cerebral Near Infrared Spectroscopy in MICS https://ClinicalTrials.gov/show/NCT01166841 Completed Lawson Health Research Institute 2011-09-30
NCT01137734 CARDINAL Adjustable Annuloplasty Ring System For Treatment of Mitral Regurgitation https://ClinicalTrials.gov/show/NCT01137734 Completed Edwards Lifesciences 2012-02-29
NCT01074671 CG Future® Annuloplasty Ring/Band Clinical Trial https://ClinicalTrials.gov/show/NCT01074671 Completed Medtronic Cardiovascular 2011-09-30
NCT01052428 Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease) https://ClinicalTrials.gov/show/NCT01052428 Completed University of Alabama at Birmingham 2010-07-31
NCT00903370 Surgical Ablation Versus No Surgical Ablation for Patients With Atrial Fibrillation Undergoing Mitral Valve Surgery https://ClinicalTrials.gov/show/NCT00903370 Completed Icahn School of Medicine at Mount Sinai 2015-09-30
NCT00853632 Magna® Mitral Pericardial Bioprostheses Post-Approval Study Protocol https://ClinicalTrials.gov/show/NCT00853632 Active, not recruiting Edwards Lifesciences 2021-12-31
NCT02771275 Safety and Early Feasibility Study of the Harpoon Medical Device (EFS) https://ClinicalTrials.gov/show/NCT02771275 Active, not recruiting Edwards Lifesciences 2017-12-31
NCT03170349 The CLASP Study Edwards PASCAL TrAnScatheter Mitral Valve RePair System Study https://ClinicalTrials.gov/show/NCT03170349 Recruiting Edwards Lifesciences 2019-12-31
NCT00807040 Comparing the Effectiveness of Repairing Versus Replacing the Heart’s Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation https://ClinicalTrials.gov/show/NCT00807040 Completed Icahn School of Medicine at Mount Sinai 2013-04-30
NCT00806988 Comparing the Effectiveness of a Mitral Valve Repair Procedure in Combination With Coronary Artery Bypass Grafting (CABG) Versus CABG Alone in People With Moderate Ischemic Mitral Regurgitation https://ClinicalTrials.gov/show/NCT00806988 Completed Icahn School of Medicine at Mount Sinai 2015-05-31
NCT03024268 MitraClip® and Hemodynamic Effects of Relevant Iatrogenic Atrial Septum Defect Closure https://ClinicalTrials.gov/show/NCT03024268 Recruiting University of Leipzig 2020-06-30
NCT02520310 AVJ-514 Japan Trial https://ClinicalTrials.gov/show/NCT02520310 Active, not recruiting Abbott Medical Devices 2016-07-31
NCT03929913 NHLBI DIR Transcatheter Mitral Cerclage Annuloplasty Early Feasibility Study https://ClinicalTrials.gov/show/NCT03929913 Recruiting National Institutes of Health Clinical Center (CC) 2024-12-31
NCT01966146 Examination of Valve Insufficiency Before and After MitraClip or TAVI Procedure by 3D Echocardiography Compared to MRI https://ClinicalTrials.gov/show/NCT01966146 Completed RWTH Aachen University 2014-10-31
NCT01931956 Real World Expanded Multicenter Study of the MitraClip® System (REALISM) https://ClinicalTrials.gov/show/NCT01931956 Completed Abbott Medical Devices 2015-02-28
NCT03891823 Transcatheter Mitral Valve Repair for the Treatment of Mitral Valve Regurgitation In Heart Failure (The EVOLVE-MR Trial) https://ClinicalTrials.gov/show/NCT03891823 Active, not recruiting Montreal Heart Institute 2021-03-31
NCT00727012 Multicenter International Trial Ring AnnulopLasty https://ClinicalTrials.gov/show/NCT00727012 Completed Abbott Medical Devices 2010-11-30
NCT00636987 Aortic or Mitral Valve Replacement With the Biocor and Biocor Supra https://ClinicalTrials.gov/show/NCT00636987 Completed Abbott Medical Devices 2015-10-31
NCT00587470 Angiotensin-II Blockade in Mitral Regurgitation https://ClinicalTrials.gov/show/NCT00587470 Completed Mayo Clinic 2001-08-31
NCT00572091 Aachen Safety and Efficacy of the Percutaneous Transvenous Mitral Annuloplasty Device to Reduce Mitral Regurgitation https://ClinicalTrials.gov/show/NCT00572091 Completed Viacor 2008-04-30
NCT00571610 Montreal Safety and Efficacy of the Percutaneous Transvenous Mitral Annuloplasty Device https://ClinicalTrials.gov/show/NCT00571610 Completed Viacor 2008-04-30
NCT00568230 Safety and Efficacy of the Percutaneous Transvenous Mitral Annuloplasty Device to Reduce Mitral Regurgitation https://ClinicalTrials.gov/show/NCT00568230 Completed Viacor 2008-04-30
NCT00567853 Safety and Efficacy Study of the Sorin 3D Annuloplasty Ring For Mitral Repair https://ClinicalTrials.gov/show/NCT00567853 Completed Sorin Group USA, Inc. 2013-06-30
NCT00554151 Mitral Adjustable Annuloplasty Ring Feasibility and Safety Study https://ClinicalTrials.gov/show/NCT00554151 Completed Abbott Medical Devices 2009-03-31
NCT00800046 A Study of Percutaneous Repair of Functional Mitral Regurgitation Using the Ancora Heart, Inc. AccuCinch® Ventricular Repair System - The CINCH-2 Study https://ClinicalTrials.gov/show/NCT00800046 Recruiting Ancora Heart, Inc. 2020-06-30
NCT00415701 Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery https://ClinicalTrials.gov/show/NCT00415701 Completed University Hospital Inselspital, Berne 2009-12-31
NCT00413998 Randomised Ischaemic Mitral Evaluation (RIME) Trial https://ClinicalTrials.gov/show/NCT00413998 Completed Imperial College London 2012-04-30
NCT00224809 Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation https://ClinicalTrials.gov/show/NCT00224809 Completed Baylor Research Institute NA
NCT00209339 Feasibility Study of a Percutaneous Mitral Valve Repair System. https://ClinicalTrials.gov/show/NCT00209339 Completed Abbott Medical Devices 2006-02-28
NCT00209274 Pivotal Study of a Percutaneous Mitral Valve Repair System https://ClinicalTrials.gov/show/NCT00209274 Completed Abbott Medical Devices 2009-11-30
NCT00166400 A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation. https://ClinicalTrials.gov/show/NCT00166400 Completed Mayo Clinic 2007-07-31
NCT00120276 RESTOR-MV: Randomized Evaluation of a Surgical Treatment for Off-Pump Repair of the Mitral Valve https://ClinicalTrials.gov/show/NCT00120276 Completed Myocor NA
NCT00082121 Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery https://ClinicalTrials.gov/show/NCT00082121 Completed Avant Immunotherapeutics NA

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03155373 The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study https://ClinicalTrials.gov/show/NCT03155373 Completed Imperial College London 2019-03-01
NCT03145376 Clinical and Geriatric Assessment in Elderly Patients Before and After TAVI or MitraClip Positioning https://ClinicalTrials.gov/show/NCT03145376 Recruiting University of Roma La Sapienza 2020-05-30
NCT03066050 Long Term Follow Up for CTSN Mitral Valve Repair Studies https://ClinicalTrials.gov/show/NCT03066050 Active, not recruiting Icahn School of Medicine at Mount Sinai 2023-05-31
NCT03038204 The Papillary Muscle Approximation Provide Stability of Mitral Valve Repair for Ischemic Mitral Regurgitation https://ClinicalTrials.gov/show/NCT03038204 Active, not recruiting The Federal Centre of Cardiovascular Surgery, Russia 2021-01-31
NCT03012178 MRI as a Predictor of Outcomes in Patients Undergoing Mitral Valve Surgery https://ClinicalTrials.gov/show/NCT03012178 Recruiting Atlantic Health System 2020-12-31
NCT02924363 Effect of MitraClip on Acute and Chronic Reverse Cardiac Remodeling Assessed by CMR: The MITRA-REVERSE Study https://ClinicalTrials.gov/show/NCT02924363 Recruiting The Methodist Hospital System 2021-12-31
NCT02831270 Acute Normovolemic Hemodilution on Serum-creatinine Concentration in Cardiac Surgery https://ClinicalTrials.gov/show/NCT02831270 Completed Konkuk University Medical Center 2016-06-30
NCT02604745 Degenerative Mitral Regurgitation in Intermediate Risk Patients https://ClinicalTrials.gov/show/NCT02604745 Recruiting Northwestern University 2020-12-31
NCT04400513 Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes https://ClinicalTrials.gov/show/NCT04400513 Recruiting Eko Devices, Inc. 2021-09-30
NCT02371863 Normal Values in Stress Echocardiographic Parameters in Patients After Successful Mitral Valve Repair for Organic MR https://ClinicalTrials.gov/show/NCT02371863 Completed UMC Utrecht 2015-12-31
NCT02355418 The Role of Myocardial Fibrosis in Degenerative Mitral Regurgitation https://ClinicalTrials.gov/show/NCT02355418 Active, not recruiting University Hospital Birmingham NHS Foundation Trust 2019-03-31
NCT02245763 STS/ACC TVT Registry Mitral Module https://ClinicalTrials.gov/show/NCT02245763 Recruiting American College of Cardiology 2019-12-31
NCT01941459 Comparison of Blood Cardioplegia and Custodiol https://ClinicalTrials.gov/show/NCT01941459 Completed Oslo University Hospital 2009-12-31
NCT01835054 Determinants of the Progression and Outcome of Mitral Regurgitation https://ClinicalTrials.gov/show/NCT01835054 Recruiting Laval University 2022-03-31
NCT01703806 Early Surgery Versus Conventional Treatment for Asymptomatic Severe Mitral Regurgitation https://ClinicalTrials.gov/show/NCT01703806 Completed Asan Medical Center 2018-12-31
NCT01617720 MITRAFIT- Cardinal Adjustable Mitral Repair Follow-up International Postmarketing Surveillance (PMS) https://ClinicalTrials.gov/show/NCT01617720 Completed Edwards Lifesciences 2016-06-30
NCT01504880 Atrioventricular Valve Regurgitation Vena Contracta; Echo Versus MRI https://ClinicalTrials.gov/show/NCT01504880 Completed Medical College of Wisconsin 2019-12-19
NCT02023762 Deep Sedation Instead of General Anaesthesia in Percutaneous Mitral Valve Repair Using the MitraClip® System https://ClinicalTrials.gov/show/NCT02023762 Completed Heinrich-Heine University, Duesseldorf 2013-12-31
NCT04177394 MitraClip EXPAND G4 Study https://ClinicalTrials.gov/show/NCT04177394 Active, not recruiting Abbott Medical Devices 2020-08-31
NCT04399499 Percutaneous Mitral Valve Repair in Cardiogenic Shock: Mitra-Shock Study https://ClinicalTrials.gov/show/NCT04399499 Recruiting IRCCS San Raffaele 2020-06-30
NCT04218578 Strain Imaging in Patients With Functional Mitral Regurgitation, Treated With MitraClip https://ClinicalTrials.gov/show/NCT04218578 Completed University of Athens 2019-02-10
NCT04161079 5-year Follow-Up Safety and Performance Evaluation of the Medtentia Annuloplasty Ring in Adults https://ClinicalTrials.gov/show/NCT04161079 Completed Medtentia International Ltd Oy 2020-01-29
NCT04156295 Percutaneous Mitral Valve Intervention: Predicting Improvements in Left Ventricular Performance https://ClinicalTrials.gov/show/NCT04156295 Recruiting Guy’s and St Thomas’ NHS Foundation Trust 2022-03-20
NCT04067635 Primary Mitral Regurgitation Repair https://ClinicalTrials.gov/show/NCT04067635 Enrolling by invitation The Methodist Hospital System 2021-06-30
NCT04051411 The Effects of Degenerative Mitral Regurgitation on Cardiac Structure and Function, Symptoms, and Exercise Capacity https://ClinicalTrials.gov/show/NCT04051411 Recruiting Atlantic Health System 2024-01-31
NCT04038879 Comparison Study of Echocardiography and Cardiovascular Magnetic Resonance Imaging in the Assessment of Mitral and Aortic Regurgitation https://ClinicalTrials.gov/show/NCT04038879 Recruiting Atlantic Health System 2023-07-31
NCT04031274 Transcatheter Treatment for Combined Aortic and Mitral Valve Disease. The Aortic+Mitral TRAnsCatheter (AMTRAC) Valve Registry https://ClinicalTrials.gov/show/NCT04031274 Enrolling by invitation Rabin Medical Center 2020-09-01
NCT04002648 Minimally Invasive or Conventional Edge-To-Edge Repair for Severe Mitral Regurgitation Due to Bileaflet Prolapse in Barlow’s Disease: Does the Surgical Approach Have an Impact on the Long-term Results? https://ClinicalTrials.gov/show/NCT04002648 Completed Ospedale San Raffaele 2016-12-01
NCT03978676 Exercise-induced in Secondary Mitral Regurgitation: Analysis of Echocardiographic Parameters at Rest Predicting the Onset of Significant Exercise-induced Mitral Regurgitation https://ClinicalTrials.gov/show/NCT03978676 Completed Groupe Hospitalier Paris Saint Joseph 2019-12-31
NCT03968601 Use of Pre-operative Global Longitudinal Strain to Predict Post-operative Left Ventricular Dysfunction in Mitral Regurgitation Surgery https://ClinicalTrials.gov/show/NCT03968601 Recruiting University Hospital, Clermont-Ferrand 2022-02-28
NCT03600688 Edwards Cardioband European Post-Market Study, MiBAND https://ClinicalTrials.gov/show/NCT03600688 Recruiting Edwards Lifesciences 2020-12-30
NCT03600051 Automated Phonocardiography Analysis in Adults https://ClinicalTrials.gov/show/NCT03600051 Completed CSD Labs GmbH 2017-01-18
NCT03592043 A Pan-Canadian, Retrospective Evaluation of MitraClip Safety and Efficacy https://ClinicalTrials.gov/show/NCT03592043 Recruiting Population Health Research Institute 2020-10-01
NCT03511716 Observational Study of the Heart Repair Technologies Mitral Bridge in Treating Mitral Valve Regurgitation https://ClinicalTrials.gov/show/NCT03511716 Active, not recruiting Heart Repair Technologies, Inc. 2020-07-31
NCT03502811 The MitraClip® EXPAND Study of the Next Generation of MitraClip® Devices https://ClinicalTrials.gov/show/NCT03502811 Active, not recruiting Abbott Medical Devices 2019-04-05
NCT03500692 MitraClip NT System Post-marketing Surveillance Study - Japan https://ClinicalTrials.gov/show/NCT03500692 Active, not recruiting Abbott Medical Devices 2019-03-31
NCT03458806 Phono- and Electrocardiogram Assisted Detection of Valvular Disease https://ClinicalTrials.gov/show/NCT03458806 Active, not recruiting University of California, San Francisco 2020-12-31
NCT01172184 Left Atrial Distensibility to Predict Left Ventricular Filling Pressure and Prognosis in Patients With Severe Mitral Regurgitation https://ClinicalTrials.gov/show/NCT01172184 Completed Kaohsiung Veterans General Hospital. 2011-01-31
NCT01162083 Identifying an Ideal Cardiopulmonary Exercise Test Parameter https://ClinicalTrials.gov/show/NCT01162083 Completed Imperial College London 2013-05-31
NCT01112566 EASE MITRAL Expertise-based Assessment Study on Clinical Efficacy of Profile 3D in MITRAL Valve Annuloplasty https://ClinicalTrials.gov/show/NCT01112566 Completed Medtronic Cardiovascular 2017-04-26
NCT01063322 New Techniques to Evaluate Mitral Regurgitation https://ClinicalTrials.gov/show/NCT01063322 Completed National Institutes of Health Clinical Center (CC) NA
NCT01052532 Molecular Mechanisms of Mitral Regurgitation—Aim 2 https://ClinicalTrials.gov/show/NCT01052532 Completed University of Alabama at Birmingham 2010-11-30
NCT04430075 MiCLASP Post Market Clinical Follow-Up (PMCF) Study https://ClinicalTrials.gov/show/NCT04430075 Recruiting Edwards Lifesciences 2020-12-31
NCT04418960 Physiological Changes of the Mitral Annulus After Annuloplasty in Barlow Disease https://ClinicalTrials.gov/show/NCT04418960 Recruiting University Hospital, Basel, Switzerland 2021-04-30
NCT03107455 MitraClip in Acute Mitral Regurgitation https://ClinicalTrials.gov/show/NCT03107455 Active, not recruiting Fundación Investigación Sanitaria en León 2019-07-01
NCT04442828 3D Echocardiography and Cardiovascular Prognosis in Mitral Regurgitation https://ClinicalTrials.gov/show/NCT04442828 Recruiting Haukeland University Hospital 2025-04-30
NCT00722748 Genomic Investigation of Cardiovascular Diseases https://ClinicalTrials.gov/show/NCT00722748 Active, not recruiting Scripps Translational Science Institute 2020-09-30
NCT00665301 Cardiac Output Pulmonary Arterial Catheter Compared to FloWaveâ„¢ 1000 https://ClinicalTrials.gov/show/NCT00665301 Completed Woolsthorpe Technologies, LLC 2008-06-30
NCT00509080 Prognosis in Asymptomatic Mitral Regurgitation (PAMIR) Study https://ClinicalTrials.gov/show/NCT00509080 Active, not recruiting University Hospital, Basel, Switzerland 2020-12-31
NCT00491452 Repair of Ischemic Mitral Regurgitation: Comparison Between Flexible and Rigid Annuloplasty Rings https://ClinicalTrials.gov/show/NCT00491452 Completed Shaare Zedek Medical Center NA
NCT00394797 Surgical Correction of Moderate Ischemic Mitral Regurgitation https://ClinicalTrials.gov/show/NCT00394797 Completed Shaare Zedek Medical Center NA
NCT00001314 Investigation of Heart Function in Patients With Heart Valve Defects https://ClinicalTrials.gov/show/NCT00001314 Completed National Institutes of Health Clinical Center (CC) NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT02506387 Belgian Mitraclip Registry https://ClinicalTrials.gov/show/NCT02506387 Recruiting Universiteit Antwerpen 2025-12-31
NCT02033811 MitraClip® Registry https://ClinicalTrials.gov/show/NCT02033811 Recruiting Heinrich-Heine University, Duesseldorf 2030-12-31
NCT01784055 NeoChord TACT Post-Market Surveillance Registry https://ClinicalTrials.gov/show/NCT01784055 Completed NeoChord 2016-07-31
NCT03962023 Prognostic Impact of Imaging Parameters in Patients With Primary Mitral Insufficiency by Prolapse (COHORTE-IM) https://ClinicalTrials.gov/show/NCT03962023 Recruiting Lille Catholic University 2034-09-30
NCT01334801 Biomarkers in Aortic Stenosis - B.A.S.S. https://ClinicalTrials.gov/show/NCT01334801 Recruiting Mayo Clinic 2025-12-31
NCT04443218 Edwards PASCAL Transcatheter Valve Repair System Registry https://ClinicalTrials.gov/show/NCT04443218 Active, not recruiting Edwards Lifesciences 2021-12-31
NCT04415138 Evaluation of Robotic-assisted Mitral Surgery With the daVinci X Surgical System https://ClinicalTrials.gov/show/NCT04415138 Active, not recruiting Cliniche Humanitas Gavazzeni 2022-12-31
NCT04293575 Transcatheter Mitral Valve Repair as Bridge Therapy to Heart Transplantation https://ClinicalTrials.gov/show/NCT04293575 Recruiting Scientific Institute San Raffaele 2020-01-01
NCT04190602 Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System https://ClinicalTrials.gov/show/NCT04190602 Recruiting NeoChord 2021-12-31
NCT03975998 Dutch-AMR: Early Mitral Valve Repair Versus Watchful Waiting in Asymptomatic Patients With Severe Mitral Regurgitation https://ClinicalTrials.gov/show/NCT03975998 Recruiting UMC Utrecht 2026-10-31
NCT03521921 GIse Registry Of Transcatheter Treatment of Mitral Valve regurgitaTiOn (GIOTTO) https://ClinicalTrials.gov/show/NCT03521921 Recruiting IRCCS Policlinico S. Donato 2021-02-01
NCT03470155 Operative Mitral Valve Reconstruction in Functional mv Insufficiency With Reduced Systolic Ventricle Function https://ClinicalTrials.gov/show/NCT03470155 Recruiting Institut für Pharmakologie und Präventive Medizin 2021-06-01
NCT04098328 Early Feasibility EXperience of Posterior Leaflet RestOration to REduce Mitral Regurgitation https://ClinicalTrials.gov/show/NCT04098328 Recruiting Polares Medical SA 2020-12-31